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Boswellia with Vitex)

Natural Choice In Rheumatism

Composition:

Boswellia serrata extract

400mg 
(contains 75% of boswellic acid)

Vitex nirgundi extract 

200mg

Dosage: One capsule twice a day or as directed by the physician.

Therapeutic action:

  • Anti inflammatory
  • Analgesic
  • Immuno modulator
  • Anti pyretic

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Pharmacology

Boswellia serrata:

Sanskrit name: Salai guggul

boswellic-acid

boswellia-serrata

 

 

 

 

 

 

 

Boswellic acid

  • Boswellic acids are a series of pentacyclic triterpene molecules that are produced by plants in the genus Boswellia.
  • Acetyl-boswellic acids also exhibit anti-inflammatory behaviour by inhibiting leukotriene synthesis. To be specific, it inhibits the activity of the enzyme 5-lipoxygenase through a non-redox reaction. Clinical trials have investigated the effectiveness of boswellic acids in treating ulcerative colitis. Boswellic acids are also thought to decrease the symptoms of asthma.
  • Unlike NSAIDs, it does not irritate the lining of the gastrointestinal tract and will not increase the risk of developing stomach ulcers. It is even used to treat ulcerative colitis.
  • Ulcerative colitis is a chronic inflammatory disease of the colon where leukotrienes are suggested to play an important role for keeping inflammation active. Boswellic acids, the biologically active ingredients of the gum resin of Boswellia serrata (Sallai guggal), have been shown to be specific, nonredox and noncompetitive inhibitors of 5-lipoxygenase, the key enzyme of leukotriene biosynthesis.
  • Boswellia works to reduce inflammation through a different mechanism. It acts to modulate the pro-inflammatory enzyme 5-lipoxygenase (5-LOX). 5-LOX is the first enzyme released in the cytokine metabolic pathway. This pathway creates leukotrienes, which are strong inflammatory substances thought to influence many disease processes including cancer, rheumatoid arthritis, & asthma. The immune modulation reduces inflammatory chemicals and symptoms of inflammation.

Vitex nirgundi

Sanskrit name: Nirgundi, Sephali

casticin

nirgundi

Structure of casticin

 

 

Structure of casticin

  • The principal constituents of the leaf juice are casticin, isoorientin, chrysophenol D, luteolin, p–hydroxybenzoic acid and D-fructose. The main constituents of the oil are sabinene, linalool, terpinen-4-ol, β-caryophyllene, α-guaiene and globulol constituting 61.8% of the oil.
  • It is a best analgesic, anti-inflammatory, antibacterial.
  • Improves appetite and digestion. It is useful in loss of appetite, anorexia, ama-dosha, hepatitis and is anthelmintic. It also improves blood circulation process.
  • It has been used for centuries to reduce inflammation and swelling of joints due to rheumatism and injuries. It is well known for reducing painful swellings.

Reference:

 

  • Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine. 2003 Jan;10 (1):3-7.
  • Pharmacokinetic study of 11-Keto beta-Boswellic acid. Phytomedicine. 2004 Feb;11 (2-3):255-60.
  • "Vitex negundo L. var. negundo". Germplasm Resources Information Network (GRIN) online database. http://www.ars-grin.gov/cgi-bin/npgs/html/taxon.pl?457404. Retrieved September 7, 2011.
  • Shallaki-medicinal uses according to Ayurveda.
  • Gupta I, Gupta V, Parihar A, Gupta S, Lüdtke R, Safayhi H, Ammon H (1998). "Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study". Eur J Med Res 3 (11): 511–4. PMID 9810030
  • www.wikipedia.com

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