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THIO ( 10's)

THIO

New product

(Thiocolchioside 8mg and Boswellia serrata Extract)

Ingredients:

Gloriosa superba extract

8mg

Boswellia serrata extract

400mg

 

Therapeutic action:

  • Anti inflammatory
  • Muscle relaxant activity
  • Analgesic and anti-spasmodic actions

Dosage: 1 capsule twice a day or as directed by the physician.

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Pharmacology

Gloria superba:

Sanskrit name: Langali

clorichine

gloria-superba

 

 

 

 

 

 

The active constituent is colchicine.

  • Mode of action includes modulation of chemokine and prostanoid production and inhibition of neutrophil and endothelial cell adhesion molecules by which it interferes with the initiation and amplification of the joint inflammation.
  • Usually gout symptoms develop suddenly and involve only one or a few joints. The big toe, knee, or ankle joints are most often affected. Gout is caused by too much uric acid in the blood. When uric acid levels in the blood are too high, the uric acid may form hard crystals in your joints.
  • Colchicine works by decreasing swelling and lessening the build up of uric acid crystals that cause pain in the affected joint.

Boswellia serrata (Shallaki):

Sanskrith name: Salai guggul

boswellia-acid

boswellia-serrata

 

 

 

 

 

Structure of α-boswellic acid 

  • It is a disease modifying agent, is beneficial in chronic inflammatory conditions. Commonly known as salai guggul, shallaki reduces joint pain and swelling and increases mobility.
  • It is absolutely safe in long term therapy and does not show any gastrointestinal side effects.
  • In clinical and preclinical studies, Boswellia serrata has been shown to contribute potent anti-inflammatory activity. Boswellic acids exert anti-inflammatory response by preventing leukotriene synthesis.
  • Produces its anti-inflammatory effect with far fewer side effects than conventional drugs such as the steroidal medication used to manage inflammation and the NSAIDs (non-steroidal anti-inflammatory drugs) used to manage pain and inflammation.
  • Shallaki is a proven, effective 100% safe and natural herbal remedy, which will act as a natural anti-inflammatory agent and provides relief to the joints and muscle tissues that are stiff and painful.
  • Researches also suggest that boswellia improves the biochemical structure of cartilage by increasing blood supply to joint, tissue, inhibiting inflammation, and other actions.
  • Are termed as non-redox inhibitors of 5-lipoxygenase. 5-liopoxygenase is responsible for the production of LTB4 from arachidonic acid at the beginning of an inflammatory response. By inhibiting it, boswellia extract targets one of the biochemical cascade reactions leading to inflammation.

Reference

 

  • AP Jain - International Journal of Pharmaceutical Research - ijprd.com
  • Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine. 2003 Jan; 10(1):3-7.
  • Pharmacokinetic study of 11-Keto beta-Boswellic acid. Phytomedicine. 2004 Feb; 11 (2-3):255-60.
  • Shallaki-medicinal uses according to Ayurveda.
  • Gupta I, Gupta V, Parihar A, Gupta S, Lüdtke R, Safayhi H, Ammon H (1998). "Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study". Eur J Med Res 3 (11): 511–4. PMID 9810030
  • www.wikipedia.com

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