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Garcinia cambogia extract,
L-carnitine, Green coffee extract,
Coleus extract, Natural Caffeine,
Ginger extract and Black Pepper extract Tablets

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Recommended Usage: One or two tablets daily or as instructed by nutritionist/dietician.

*THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE

  • Helps speed up weight loss Naturally
  • Appetite Control
  • Helps Convert Fat into Mass & Enery
  • Improves Athletic Performance, Increase mental focus
  • Boosts metabolism by helping in fat burning
  • Increase cognitive function
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Indication of TRIMPIL Tablet

  • Helps speed up weight loss Naturally.
  • Appetite control.
  • Helps convert fat into mass & energy.
  • Improves Athletic performance, Increases mental focus.
  • Boosts metabolism by helping in fat burning.
  • Increases cognitive functions.

CONTRAINDICATIONS

No specific contraindications when administered as per advised dosage.

Packing style

Bottle packing of 30’s, 60’s, 100’s & 200’s, 500’s & 1000’s.

Individual ingredient and clinical trial data :

1. Garcinia cambogia

  • HCA in Garcinia extract speeds by weight loss naturally :

Garcinia extract, hydroxycitric acid (HCA) as a weight reduction agent. Hydroxycitric acid is a chemical that found in fruit rinds of Garcinia cambogia. Hydroxy citric acid in Garcinia cambogia extract (100% water soluble) speeds by weight loss naturally, suppresses your appetite and present storage of fat into body.

Reference : 1. The effect of Garcinia Cambogia as coadjuvant in the weight loss process- Patricia Fassina1, Fernanda Scherer Adami2, Valdeni Terezinha Zani 2,3, Isabel Cristina Kasper Machado 2, 3, Juliano Garavaglia 2,3, Magali Terezinha Quevedo Grave1, Renata Ramos3 and Simone Morelo Dal Bosco1, 2 – Nutr Hosp. 2015;32 (6) : 2400-2408)

2.The Use of Garcinia Extract (Hydroxycitric Acid) as a Weight loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials
Igho Onakpoya,* Shao Kang Hung, Rachel Perry, Barbara Wider, and Edzard Ernst
J Obes. 2011; 2011: 509038. Published online 2010 Dec14. doi: 10.1155/2011/509038

  • Appetite suppression /Hunger control effect of HCA on metabolism :
Garcinia cambogia-derived natural (-)-hydroxycitric acid (HCA) in weight management by curbing appetite and inhibiting body fat biosynthesis. Garcinia cambogia to burn fat and suppressed the appetite. The aim of this study is to assess the uses of products containing Garcinia cambogia to burn fat and suppressed the appetite.
Several mechanisms of action have been linked to the weight loss effect of HCA through prior animal studies, including: 1. Inhibition of lipogenesis through adenosine triphosphate (ATP) citrate lyase inhibition, which prevents the conversion of carbohydrate to fat. 2. Suppression of appetite through increasing glycogen storage thus stimulating the glucoreceptors in the liver and inducing satiety via vagus nerve. 3. Reduction of the hunger feeling by increasing the level of serotonin and 4. Improved glucose metabolism through regulation of leptin and insulin plasma level.

Reference : 1. Evidence of Garcinia cambogia as a fat burning and appetite suppressing agents-Authors: Wan Nur Asyiken Wan Ab Rahman, Kah Seng Lee, June Choon Wai Yee, Manish Gupta and Long Chiau Ming. Date: January-March 2016 from: Archives of Pharmacy Practice(Vol. 7, Issue S1) Publisher: Archives of Pharmacy Practice.

Evidence of Garcinia cambogia as a fat burning and appetite suppressing agents Wan Nur Asyiken Wan Ab Rahman1, Kah Seng Lee2, June Choon Wai Yee3, Manish Gupta3, Long Chiau Ming1,4-© 2016 Archives of Pharmacy Practice | Published by Wolters Kluwer – Medknow

  • Role of HCA in fat production inhibition :

G cambogia reduced abdominal fat accumulation in subjects, who had the visceral fat accumulation type of obesity. No rebound effect was observed. It is therefore expected that G cambogia may be useful for the prevention and reduction of accumulation of visceral fat.

 Hydroxycitric acid, the active ingredient in the herbal compound Garcinia cambogia, competitively inhibits the extramitochondrial enzyme adenosine triphosphate-citrate (pro-3S)-lyase. As a citrate cleavage enzyme that may play an essential role in de novo lipogenesis inhibition, G cambogia is claimed to lower body weight and reduce fat mass in humans.

Reference : 1. Effects of garcinia cambogia (Hydroxycitric Acid) on visceral fat accumulation: a double-blind, randomized, placebo-controlled trial.

Kohsuke Hayamizu, MS 1,2,* Yuri Ishii, MS,1 Izuru Kaneko, DVM,1 Manzhen Shen, PhD,1 Yasuhide Okuhara, BS,1 Norihiro Shigematsu, PhD,1 Hironori Tomi, PhD, 3 Mitsuhiro Furuse, PhD, 2 Gen Yoshino, MD, PhD, 4 and Hiroyuki Shimasaki, PhD5-Journal List , Curr Ther Res Clin Exp, v.64 (8); 2003 Sep-PMC4053034

2. L-Carnitine-L-Tartarate

  • Role in the convertion of fat into mass and energy :

L-carnitine is popular as a potential ergogenic aid because of its role in the conversion of fat into energy and mass. L-carnitine’s main role in your body involves mitochondrial function and energy production.

Reference : . Effect of L-carnitine Supplementation on Nutritional Status and Physical Performance Under Calorie Restriction -Swati Jain and Som Nath Singh- Journal List Indian J Clin Biochem . v.30(2); 2015 Apr-PMC4393395

  • The role of L-Carnoitine in weight management and boosts metabolism :

L -carnitine is a molecule involved in the oxidation of fatty acids in the mitochondria. It is a non-essential amino acid and is produced from two amino acid substrates, L-lysine and L-methionine. L-carnitine benefits weight loss by transporting fatty acids to the mitochondrial matrix, where they get oxidized, and energy is released. This process helps to burn the fat and the energy released is used to boost exercise performance and improve endurance and muscle power.

Reference :  A Pilot Clinical Trial on L-Carnitine Supplementation in Combination with Motivation Training: Effects on Weight Management in Healthy Volunteers Satoshi Odo1 , Koji Tanabe1 , Masamitsu Yamauchi- Food and Nutrition Sciences, 2013, 4, 222-231 doi:10.4236/fns.2013.42030 Published Online February 2013  (http://www.scirp.org/journal/fns)

  • L-carnitine for cognitive enhancement in people without cognitive impairment :

L-carnitine on physical and mental fatigue and on cognitive functions . L‐carnitine for the enhancement of cognitive function in people without cognitive impairment.

Reference : L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial1–3 Mariano Malaguarnera, Lisa Cammalleri, Maria Pia Gargante, Marco Vacante, Valentina Colonna, and Massimo Motta- Am J Clin Nutr 2007;86:1738–44. Printed in USA. © 2007 American Society for Nutrition.

L‐carnitine for cognitive enhancement in people without cognitive impairment Ning Chen, Mi Yang, Muke Zhou, Jing Xiao, Jian Guo, and Li He- Journal List , Cochrane Database Syst Rev-PMC6464592

  • Role of L-carnitine in Improve stamina and lean body :

To assess the efficacy of L-carnitine supplementation on lean body mass in male body builders. It has been hypothesized that since L-carnitine is involved in the transport of fatty acids across the mitochondrial membrane, supplementation might enhance fatty acid oxidation and thereby improve endurance and performance allowing for a greater training effect.

Reference : The effect of L-Carnitine Supplimentation on lean body mass in male amateur body builders. R.E.Green, MS, RD. A.M. Levine, Phd,RD. M.J. Gunning, EdD. L.S.Walsh, MS-DOI: https://doi.org/10.1016/S0002-8223(97)00569-5

3. Green coffee bean extract

  • Action of Chlorogenic acid in Boosts metabolism by helping in fat burning :

Green coffee bean can boost your metabolism and minimize the release of glucose in the bloodstream, so the body starts using excess fat resulting in weight loss.

Reference : 1. The role of green coffee extract on weight loss, glucose and lipid metabolism Mehdi Fasihi1, Ali Barzegar2, Mahmood Alizadeh Sani3-Progress in Nutrition 2019; Vol. 21, Supplement 2: 14-21 DOI: 10.23751/pn.v21i2-S.6260

  • The use of Green coffee extract as a weight loss supplement :

Green coffee enhances energy metabolism and reduces lipogenesis by down regulating SREBP-1c (Sterol regulatory element-binding protein) and related molecules, which leads to the suppression of body fat accumulation [11]. Scientific theories expressed that natural substances found in green coffee prevent weight gain and fat accumulation by inhibiting fat absorption and increasing fat metabolism in liver [23,29]. Supplementation with coffee polyphenols can also be effective in weight loss and reduce abdominal and liver fat accumulation by inhibition of macrophages infiltration into adipose tissues.

Reference : Green Coffee Bean Extract as a Weight Loss Supplement Mehnoosh Samadi1 , Majid Mohammadshahi2 and Fatemeh Haidari2 * 1 Department of Nutrition, Paramedical School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran 2 Nutrition and Metabolic Diseases Research Centre, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61357-15794, Iran- Samadi et al., J Nutr Disorders Ther 2015, 5:4 DOI: 10.4172/2161-0509.1000180

  • Reduces risk of chronic diseases like diabetes and heart disease :

Observational research showing consumption of green coffee bean is reduce the risk of chronic diseases.

Reference: Consumption of Green Coffee and the Risk of Chronic Diseases, April 2018 Critical Reviews in Food Science and Nutrition 59(12):1-39 DOI:10.1080/10408398.2018.1461061. Authors: Nevin Sanlİer, Azize Atİk İlker Atİ

  • Natural Antioxidant

Green coffee beans are rich in phenolic compounds and is known for its antioxidant properties. Strong antioxidant properties of green coffee extracts and their significant ability to reduce iron and copper metal ions should be combined with a high content of active compounds, such as polyphenolic compounds.

Reference: Antioxidant Properties of Green Coffee Extract Anna Masek 1,*, Malgorzata Latos-Brozio 1 , Joanna Kałużna-Czaplińska 2 , Angelina Rosiak 2 , Ewa Chrzescijanska 2- Forests 2020, 11, 557; doi:10.3390/f11050557

4. Coleus forskohlii extract

  • Increases fat loss rate by releasing stored fat from fat cells :

Reference: Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial Hayley L. Loftus, Katie J. Astell, Michael L. Mathai, and Xiao Q. Su*-Nutrients. 2015 Nov; 7(11): 9508–9522. Published online 2015 Nov 17. doi: 10.3390/nu7115483

  • Coleus forskohlii extract may aid in weight management :

The C. forskohlii extract showed a substantial effect on weight loss and was safe and effective in reducing body fat in overweight/obese people.

Reference :  An evidence-based review: Anti-obesity effects of Coleus forskohlii, April 2016, DOI:10.1016/j.pmu.2016.02.001. Authors: Seika Kamohara- Nutrients. 2015 Nov; 7(11): 9508–9522. Published online 2015 Nov 17. doi: 10.3390/nu7115483

  • Diterpenoid in Coleus forskohlii supports cardiovascular health :

Forskolin has a particularly beneficial effect on the cardiovascular system. It works via vasorelaxation, causing relaxation of smooth muscles in the walls of blood vessels, which results in increasing the overall volume of the circulatory system while maintaining the volume of blood.

Reference : The Therapeutic Potential of the Labdane Diterpenoid Forskolin Bahare Salehi 1 , Mariola Staniak 2 , Katarzyna Czopek 2 , Anna St˛epie ´n 2 , Kamal Dua 3,4,5,*, Ridhima Wadhwa 6 , Dinesh Kumar Chellappan 7 , Oksana Sytar 8,9 , Marian Brestic 9 , Namrata Ganesh Bhat 10, Nanjangud Venkatesh Anil Kumar 10 , María del Mar Contreras 11,* , Farukh Sharopov 12,* , William C. Cho 13,* and Javad Sharifi-Rad 14,* Appl. Sci. 2019, 9, 4089; doi:10.3390/app9194089

  • Helps to increase testosterone levels

Serum free testosterone levels were significantly increased in the forskohlii group.

Reference : Body Composition and Hormonal AdaptationsAssociated with Forskolin Consumption inOverweight and Obese Men. Michael P. Godard, Brad A. Johnson, and Scott R. Richmond. OBESITY RESEARCH Vol. 13 No. 8 August 200

5. Natural Caffeine (From Green Coffee)

  • Caffeine intake is related to successful weight loss maintenance

Reference : Caffeine intake is related to successful weight loss maintenance. November 2015. European Journal of Clinical Nutrition 70(4) , DOI : 10.1038/ejcn.2015.183

Authors : Dina Icken, Hannover Medical School, S Feller, Stefan Engeli University of Greifswald, Andreas Mayr University of Bonn.

  • Role of caffeine on significally decrease BMI & body fat :

Reference : Green  coffee  bean  extract  improves  obesity  by  decreasing  body  fat  in  high-fat  diet-induced  obesemice. Bong-Keun ChoiSung-Bum ParkDong-Ryung LeeHae Jin LeeYing-Yu JinSeung Hwan YangJoo-Won Suh. Bong-Keun Choi et al./Asian Pacific Journal of Tropical Medicine 2016; 9 (7): 635–643636

  • Natural caffeine Increases cognitive functions :

Caffeine is considered to be an ergogenic ‘drug’ with beneficial effects on both physical and mental performance.

Reference : Caffeine improves physical and cognitive performance during exhaustive exercise. Publisher: Lippincott, Williams & Wilkins / c American College of Sports Medicine. Eef Hogervorst1 MSc, PhD, Stephan Bandelow1 BA, MS, DPhil, Jeroen Schmitt3 MSc, PhD, Roy Jentjens3 MSc, PhD, Marta Oliveira2 BSc, MSc, Judith Allgrove2 BSc, MSc, Tom Carter 1 BSc, MRes, Michael Gleeson2 BSc, PhD.. Loughborough University Institutional Repository.

  • Role on boosts everyday energy and physical endurance :

Caffeine use is increasing worldwide. The underlying motivations are mainly concentration and memory enhancement and physical performance improvement.

Reference : Caffeine: Cognitive and Physical Performance Enhancer or Psychoactive Drug? Simone Cappelletti,1 Piacentino Daria,2 Gabriele Sani,2 and Mariarosaria Aromatario1,* Journal List Curr Neuropharmacol, v.13(1); 2015 Jan. PMC4462044

6.Ginger extract

  • Supports Digestion :

Ginger works by increasing ‘digestive fire’, which further helps in better break down and assimilation of food. Apart from this, ginger is also known to stimulate saliva, bile and gastric enzymes that aid digestion and help speed the movement of food from the stomach to the small intestine.

  • Gingerol and shogaols in ginger may help with weight loss :

Reference : Ginger on Human Health : A Comprehensive Systematic Review of 109 Randomized Controlled Trials. Nguyen Hoang Anh,1 Sun Jo Kim,1 Nguyen Phuoc Long,1 Jung Eun Min,1 Young Cheol Yoon,1 Eun Goo Lee,1 Mina Kim,1 Tae Joon Kim,1 Yoon Young Yang,1 Eui Young Son,1 Sang Jun Yoon,1 Nguyen Co Diem,2 Hyung Min Kim,1 and Sung Won Kwon1,* Journal List Nutrients v.12(1); 2020 Jan PMC7019938

The effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: A systematic review and meta-analysis of randomized controlled trials Najmeh Maharlouei, Reza Tabrizi, Kamran B. Lankarani, Abbas Rezaianzadeh, Maryam Akbari, Fariba Kolahdooz

  • Role of ginger on calms and soothes digestive tract and support healthy GI flora :

Reference: Clinical Evaluation of the Use of Ginger Extract in the Preventive Management of Motion Sickness Carlos Pereira Nunes, MD 1 , Claudio de Campos Rodrigues, MD 1,  Carlos Alfredo Franco Cardoso, MD 1 , Natasha Cytrynbaum, MD 2 , Renato Kaufman, MD, PhD 2 , Helio Rzetelna, MD 3 , Gerson Goldwasser, MD 3 , Alessandra Santos, MD 4 , Lisa Oliveira, MS 4 , Mauro Geller, MD, PhD. C.P. Nunes, C.d.C. Rodrigues and C.A.F. Cardoso et al. / Current Therapeutic Research 92 (2020) 100591

  • Gingerol has Powerful antioxidant in ginger :

Ginger (Zingiber officinale Rosc.) belongs to the family Zingiberaceae. The health-promoting perspective of ginger is attributed to its rich phytochemistry. This study aimed to review the current evidence on ginger effects as an anti-inflammatory and anti-oxidative.

Reference : Anti-Oxidative and Anti-Inflammatory Effects of Ginger in Health and Physical Activity: Review of Current Evidence  Nafiseh Shokri Mashhadi, Reza Ghiasvand,1,2 Gholamreza Askari,1,2 Mitra Hariri,1,2 Leila Darvishi,1,2 and Mohammad Reza Mofid3. Journal List, Int J Prev Med . v.4 (Suppl 1); 2013 Apr PMC3665023

7.Black Pepper extract (95% Piperine)

  • Natural Bioavailability enhancer :

Pepper as a bioavailability enhancer of drugs as well as nutrients. Bioenhancers can be defined as chemical entities, which when mixed with drugs promote and augment their bioavailability without showing any synergistic effect with the drug. The factors like toxicity, cost, poor bioavailability and long term administration of drugs give rise to the need of bioenhancers which help overcome most of these problems. Piper species produce a pungent alkaloid named Piperine or 1-peperoyl piperidine. Piperine increases permeability at the site of absorption by modulating lipid environment and membrane dynamics. Piperine has a molecular structure that is suitable for enzyme inhibition. It augments the bioavailability of several drugs like carbamazepine, curcumin, ciprofloxacin, ampicillin, metronidazole, oxytetracycline and many others by inhibiting various metabolizing enzymes. Thus piperine, being an efficacious inhibitor of drug metabolism is a powerful enhancer of absorption.

Reference : Molecular targets of pepper as bioavailability enhancer Priyanshee Gohil and Anita Mehta* Department of Pharmacology, LM College of Pharmacy, Navrangpura, Ahmedabad–380009, Gujarat, India Received for publication January 21, 2008; accepted March 20, 2009. 2009 Oriental Pharmacy and Experimental Medicine 9(4), 269-276

Role of Piperine as an Effective Bioenhancer in Drug Absorption Mhaske DB*, Sreedharan S and Mahadik KR Department of Pharmaceutical Chemistry, Bharati Vidyapeeth (Deemed to be) University, Pune, Maharashtra, India. Pharm Anal Acta, an open access journal ISSN: 2153-2435

  • Black pepper improves digestion and promotes intestinal health :

Reference : Nutritional Constituent of Black Pepper as Medicinal Molecules: A ReviewMurlidhar Meghwal and Goswami TK*Agricultural and Food Engineering Department (AgFE), Indian Institute of Technology (IIT) Kharagpur, 721302, India. Corresponding author: Goswami TK Professor, Agricultural and Food Engineering Department (AgFE)

  • Piperine on black pepper to boost the metabolism :

 Reference : Effects of piperine on lipid metabolism in high-fat diet induced obese mice. Yafang DuYuzhong ChenXiaoya FuJia GuYue SunZixiang ZhangJiaying XuLiqiang Qin. Journal of Functional Foods 71 (2020) 1040112

  • Role of Piperine on reduces inflammation :

Reference : Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1β-stimulated fibroblast-like synoviocytes and in rat arthritis models. Bong-Jun Sur,2 Sung-Jig Lim,3 Jung Yeon Kim,4 Hyung-In Yang,5 Myung Chul Yoo,6 Dae-Hyun Hahm,  2 and Kyoung Soo Kim 1 Arthritis Res Ther. 2009; 11(2): R49. Published online 2009 Mar 30. doi: 10.1186/ar2662